11-Deoxy Prostaglandin E2

11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions[1][2].

Product Specifications

CAS Number

[35536-53-9]

UNSPSC

12352211

Hazard Statement

H302, H360

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/11-deoxy-prostaglandin-e2.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

CCCCC[C@@H](/C=C/[C@@H](CCC1=O)[C@H]1C/C=C\CCCC(O)=O)O

Molecular Formula

C20H32O4

Molecular Weight

336.47

Precautions

H302, H360

References & Citations

[1]Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20 (1) :37.|[2]Ungrin MD, et al. Key structural features of prostaglandin E (2) and prostanoid analogs involved in binding and activation of the human EP (1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59 (6) :1446-56.