Exatecan Intermediate 2 (hydrochloride)
Product Specifications
UNSPSC Description
Exatecan Intermediate 2 hydrochloride (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2].
Target Antigen
ADC Cytotoxin; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-2-hydrochloride.html
Purity
99.94
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
CC(NC(CCC1=C2C(N)=CC(F)=C1C)C2=O)=O.Cl
Molecular Weight
286.73
References & Citations
[1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.|[2]Lv Xianyu, et al. Preparation of camptothecin derivative intermediate. China, CN115197088. 2022-10-18.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W021377A/Exatecan-Intermediate-2-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W021377A/Exatecan-Intermediate-2-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2437603-23-9
Available Sizes
Curated Selection
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