Phrixotoxin 2

Phrixotoxin 2 is a highly selective KV4.2 and KV4.3-channels blocker[1].

Product Specifications

CAS Number

741738-57-8

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phrixotoxin-2.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CC1=CC=C(O)C=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(N)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H]3CC5=CNC6=CC=CC=C56)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O)=O)CC7=CNC8=CC=CC=C78)=O)CCSC)=O)CC9=CNC%10=CC=CC=C9%10)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]4C(C)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O

Molecular Formula

C169H259N49O43S8

Molecular Weight

3921.69

References & Citations

[1]M. Gostimirovic, et al. Involvement of phrixotoxin-2 sensitive KV4 family of potassium channels in the relaxation mediated by resveratrol in human saphenous vein from diabetic patients. Abstracts / Atherosclerosis 331 (2021) e56ee293.