PCSK9-IN-13

PCSK9-IN-13 (compound 3f) is a potent PCSK9 inhibitor, which can antagonize low-density lipoprotein (LDL) receptor binding by binding to PCSK9, with an IC50 of 537 nM[1].

Product Specifications

CAS Number

[2244129-23-3]

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pcsk9-in-13.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(OC2=CC=CC=C2)=C(C=C1)C)NC3=CC(N4C=C(N=C4)C)=CC(CN5C[C@H](CCC5)N)=C3

Molecular Formula

C30H33N5O2

Molecular Weight

495.62

References & Citations

[1]Benny J. Evison, et al. A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.Bioorganic & Medicinal Chemistry