2-Iodomelatonin
Product Specifications
UNSPSC Description
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 ?over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].
Target Antigen
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-iodomelatonin.html
Purity
99.04
Solubility
DMF : 30 mg/mL (ultrasonic;warming)|DMSO : 30 mg/mL (ultrasonic;warming)|Ethanol : 20 mg/mL (ultrasonic;warming)
Smiles
CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O
Molecular Weight
358.17
References & Citations
[1]Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166(9):5792-800.|[2]Wang X, et al. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.J Neurosci. 2011 Oct 12;31(41):14496-507.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101176/2-Iodomelatonin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101176/2-Iodomelatonin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
93515-00-5
Available Sizes
Curated Selection
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