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2-Iodomelatonin

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

Product Specifications

CAS Number

[93515-00-5]

UNSPSC

12352005

Target

Melatonin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-iodomelatonin.html

Purity

99.04

Solubility

DMF : 30 mg/mL (ultrasonic; warming) |DMSO : 30 mg/mL (ultrasonic; warming) |Ethanol : 20 mg/mL (ultrasonic; warming)

Smiles

CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O

Molecular Formula

C13H15IN2O2

Molecular Weight

358.17

References & Citations

[1]Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166 (9) :5792-800.|[2]Wang X, et al. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.J Neurosci. 2011 Oct 12;31 (41) :14496-507.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101176/2-Iodomelatonin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101176/2-Iodomelatonin-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MT1

Available Sizes

Curated Selection

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