Ara-F-NAD+ (sodium)

Ara-F-NAD+ sodium is an arabino analogue of NAD+. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor[1][2].

Product Specifications

UNSPSC

12352005

Target

CD38

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ara-f-nad-sodium.html

Purity

99.81

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H]4[C@@H](O)[C@H](F)[C@H]([N+]5=CC=CC(C(N)=O)=C5)O4)([O-])=O)(O[Na])=O)O3

Molecular Formula

C21H25FN7NaO13P2

Molecular Weight

687.40

References & Citations

[1]Berthelier V, et al. Human CD38 is an authentic NAD (P) + glycohydrolase. Biochem J. 1998;330 (Pt 3) (Pt 3) :1383-1390.|[2]Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19 (10) :15754-15767. Published 2014 Sep 29.