Topoisomerase II inhibitor 18
Selected Variant
HY-162380
Size: 1 Each
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC50 of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer[1].
Product Specifications
CAS Number
2382959-65-9
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-18.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC)CCSC1=NC2=CC=CC=C2N=C1C3=CC=CC=C3
Molecular Formula
C20H21N3OS
Molecular Weight
351.47
References & Citations
[1]Elsakka MEG, et al., A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition. J Biomol Struct Dyn. 2024 Mar 14:1-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
NUN-C52Hc-100ug 100 µg
SARS-CoV-2 Nucleocapsid protein (P80R), His Tag
Sign In for Pricing
View Details 
ER1803-90 100 µL
G-protein coupled receptor 30 Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
PA2019-iFluor647 100 µg
Anti-CETP Antibody Picoband®, iFluor647 Conjugate
Sign In for Pricing
View Details