Topoisomerase II inhibitor 18

Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC50 of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer[1].

Product Specifications

CAS Number

[2382959-65-9]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-18.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCC)CCSC1=NC2=CC=CC=C2N=C1C3=CC=CC=C3

Molecular Formula

C20H21N3OS

Molecular Weight

351.47

References & Citations

[1]Elsakka MEG, et al., A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition. J Biomol Struct Dyn. 2024 Mar 14:1-19.