Tiazofurin
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH) . Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer[1][2][3][4].
Product Specifications
CAS Number
60084-10-8
Product Name Alternative
NSC 286193; Riboxamide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Nucleoside Antimetabolite/Analog; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tiazofurin.html
Purity
99.84
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CSC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=N1
Molecular Formula
C9H12N2O5S
Molecular Weight
260.27
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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