Epoxyazadiradione

Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF) ) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM) . Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human[1].

Product Specifications

CAS Number

[18385-59-6]

UNSPSC

12352005

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/epoxyazadiradione.html

Purity

99.24

Solubility

DMSO : ≥ 50 mg/mL

Smiles

C[C@]12[C@]34[C@]([C@@](C5=COC=C5)([H])C([C@@]3([H])O4)=O)(CC[C@]1([H])[C@@]6([C@@](C(C)(C(C=C6)=O)C)([H])C[C@H]2OC(C)=O)C)C

Molecular Formula

C28H34O6

Molecular Weight

466.57

References & Citations

[1]Alam A, et al. Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. J Biol Chem. 2012;287 (29) :24844-24861.