GMP Human IL-18 Protein
GMP Human IL-18 Protein (GMP-L18H16) is expressed from E. coli cells. It contains AA Tyr 37 - Asp 193 (Accession # Q14116) .
Product Specifications
Background
Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-gamma (IFN-gamma) production from Th1 cells, NK cells and activated macrophages, particularly in the presence of IL-12. IL-18 also functions in developmental regulation of T-lymphocyte helper type I cells and in Fas-mediated cytotoxicity. Suppression of IL-18 activity is being investigated for treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. It acts by inducing heterodimerization of the two subunits of its receptor, IL-18RAlpha and IL-18RBeta shows structural similarity to IL-1.
Specifications
This protein carries no "tag". The protein has a calculated MW of 18.2 kDa. The protein migrates as 17 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .
Accession Number
Q14116
Expression Region
Tyr 37 - Asp 193
Host
E. coli
Target
IL-18
Conjugation
Unconjugated
Tag
Native
Stability
● -20°C to -70°C for 5 years in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin
10 EU/mg
Purity
95%
Format
Powder-GMP
Buffer
PBS, pH7.4
Molecular Weight
18.2 kDa
Shipping Conditions
Blue ice
Storage Conditions
-20°C
Package Size
50ug*200
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/GMP-L18H16.pdf
Species
Human
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