GMP Human IL-18 Protein
Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-gamma (IFN-gamma) production from Th1 cells, NK cells and activated macrophages, particularly in the presence of IL-12. IL-18 also functions in developmental regulation of T-lymphocyte helper type I cells and in Fas-mediated cytotoxicity. Suppression of IL-18 activity is being investigated for treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. It acts by inducing heterodimerization of the two subunits of its receptor, IL-18RAlpha and IL-18RBeta shows structural similarity to IL-1.
Product Specifications
Background
Specifications
Accession Number
Q14116
Expression Region
Tyr 37 - Asp 193
Host
E. coli
Target
IL-18
Conjugation
Unconjugated
Tag
Native
Stability
Endotoxin
10 EU/mg
Purity
95%
Format
Powder-GMP
Buffer
PBS, pH7.4
Molecular Weight
18.2 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Blue ice
Storage Conditions
-20°C
Package Size
50ug*200
Host or Source
E. coli
Species
Human
Protein ID
Q14116
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