GMP Human TNF-alpha Protein
GMP Human TNF-alpha Protein (GMP-TNAH23) is expressed from human 293 cells (HEK293) . It contains AA Val 77 - Leu 233 (Accession # P01375) .
Product Specifications
Background
Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Specifications
This protein carries no "tag". The protein has a calculated MW of 17.4 kDa. The protein migrates as 17 kDa±3 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P01375
Expression Region
Val 77 - Leu 233
Host
HEK293
Target
TNF-alpha
Conjugation
Unconjugated
Tag
Native
Stability
● -20°C to -70°C for 5 years in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin
10 EU/mg
Purity
95%
Format
Powder-GMP
Buffer
PBS, pH7.4
Molecular Weight
17.4 kDa
Shipping Conditions
Blue ice
Storage Conditions
-20°C
Package Size
50ug*200
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/GMP-TNAH23.pdf
Species
Human
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
