Human LIGHT / TNFSF14 Protein, His Tag, Ultra Low Endotoxin (MALS verified)
Human LIGHT Protein, His Tag (LIT-H5243) is expressed from human 293 cells (HEK293) . It contains AA Asp 74 - Val 240 (Accession # O43557-1) .
Product Specifications
Background
Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR) . LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 58.3 kDa. The protein migrates as 50-60 kDa and 65-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Accession Number
O43557-1
Expression Region
Asp 74 - Val 240
Host
HEK293
Target
LIGHT
Conjugation
Unconjugated
Tag
N-10xHis
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
0.0005 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
58.3 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
1mg*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/LIT-H5243.pdf
Species
Human
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