Human Kallikrein 5 Protein, Tag Free (active enzyme)
Human Kallikrein 5 Protein, Tag Free (KA5-H5213) is expressed from human 293 cells (HEK293) . It contains AA Ile 67 - Ser 293 (Accession # Q9Y337-1) .
Product Specifications
Background
Kallikrein 5 (KLK5), a serine protease encoded by the KLK5 gene, regulates skin desquamation by activating kallikrein proteases (e.g., KLK7) and degrading corneodesmosomes. In cancer, KLK5 exhibits dual roles: while overexpressed in colorectal and pancreatic cancers promotes metastasis via ECM degradation, its elevated expression in breast cancer suppresses tumor growth by inhibiting RhoA and modulating the mevalonate pathway. Dysregulated KLK5 activity drives inflammatory skin disorders through excessive cleavage of cathelicidins. Therapeutic strategies include covalent inhibitors for inflammatory diseases and KLK5-enhancing approaches in breast cancer. Serum KLK5 levels serve as biomarkers for fibrosis and cancer prognosis.
Specifications
This protein carries no "tag". The protein has a calculated MW of 25.2 kDa. The protein migrates as 33-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q9Y337-1
Expression Region
Ile 67 - Ser 293
Host
HEK293
Target
Kallikrein 5
Conjugation
Unconjugated
Tag
Native
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Purity
95%
Format
Powder
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
25.2 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/KA5-H5213.pdf
Species
Human
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