Alexa Fluor™ 647-Labeled Human Alpha-synuclein Protein, His Tag
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD) . Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Product Specifications
Background
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa.
Accession Number
P37840-1
Expression Region
Met 1 - Ala 140
Host
E. coli
Target
Alpha-Synuclein
Conjugation
AF647 Labeled
Tag
C-10xHis
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
0.1 EU per μg
Purity
90%
Format
Liquid
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
16.3 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C, avoid light
Package Size
1mg*1
Host or Source
E. coli
Species
Human
Protein ID
P37840-1
Preservative
Trehalose
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