1400W (Dihydrochloride)

1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730) . 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].

Product Specifications

CAS Number

[214358-33-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; NO Synthase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/1400W_Dihydrochloride.html

Purity

99.94

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl

Molecular Formula

C10H17Cl2N3

Molecular Weight

250.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272 (8) :4959-63.|[2]Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199.