Aerothionin

Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs) [1][2].

Product Specifications

CAS Number

[28714-26-3]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/aerothionin.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@@]2(C=C(C(OC)=C1Br)Br)CC(C(NCCCCNC(C3=NO[C@@]4([C@H](C(Br)=C(C(Br)=C4)OC)O)C3)=O)=O)=NO2

Molecular Formula

C24H26Br4N4O8

Molecular Weight

818.10

References & Citations

[1]Drechsel A, et al., Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro. Mar Drugs. 2020 May 1;18 (5) :236.|[2]Šimovičová M. Synthesis of aerothionin analogs as potential antimycobacterial agents[J]. 2021.