Alatrioprilat
Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM) . Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF) . Alatrioprilat can be used in the study of cardiovascular diseases[1].
Product Specifications
CAS Number
135038-59-4
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/alatrioprilat.html
Smiles
OC([C@H](C)NC([C@@H](CS)CC1=CC=C(OCO2)C2=C1)=O)=O
Molecular Formula
C14H17NO5S
Molecular Weight
311.35
References & Citations
[1]Gros C, et al. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4. 15.1) and enkephalinase (EC 3.4. 24.11) : rational design, properties, and potential cardiovascular applications of glycopril and alatriopril[J]. Proceedings of the National Academy of Sciences, 1991, 88 (10) : 4210-4214.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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