PE Anti-Human CD192/CCR2 Antibody[K036C2]
This is a PE Anti-Human CD192/CCR2 [K036C2] Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4) . Two spliced variants were initially described for CCR2 (CCR2A and CCR2B) . These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
Synonyms
CKR2, CCR2A, CCR2B, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2
Gene ID
729230
Reactivity
Human
Clonality
Monoclonal
Conjugation
PE
Type
Flow Cytometry Antibody
Applications
FC
Assay Type
Antibody
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.
Host or Source
Mouse
Isotype
Mouse IgG2a, κ
Available Sizes
Curated Selection
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