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SARS-CoV-2 NSP3 Polyclonal Antibody (2019-nCoV)

This is a SARS-CoV-2 NSP3 (2019-nCoV) Virus Antibody from Reddot Biotech. This product is for Research Use Only.

Product Specifications

Background

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.

Synonyms

Non-structural protein 3, PL2-PRO, Papain-like proteinase, PL-PRO, Replicase polyprotein 1a

Reactivity

SARS-COV2

Immunogen

Recombinant SARS-CoV-2 NSP3

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Virus Antibody

Applications

ELISA

Purification Method

Produced in rabbits immunized with purified, Recombinant SARS-CoV-2 NSP3 protein

Assay Type

Antibody

Concentration

0.33mg/mL

Dilution

ELISA 1:4000-1:8000

Buffer

PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Host or Source

Rabbit

Isotype

IgG

Available Sizes

Curated Selection

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