Evofosfamide
Evofosfamide (TH-302) is a hypoxia-activated proagent with IC50 of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.
Product Specifications
CAS Number
918633-87-1
Product Name Alternative
TH-302
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TH-302.html
Purity
98.0
Solubility
DMSO : 94 mg/mL (ultrasonic; warming) |H2O : 4.35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(NCCBr)(OCC1=CN=C(N1C)[N+]([O-])=O)NCCBr
Molecular Formula
C9H16Br2N5O4P
Molecular Weight
449.04
Precautions
H302, H315, H319, H335
References & Citations
18
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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