RRP8 Polyclonal Antibody
This is a RRP8 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Essential component of the eNoSC (energy-dependent nucleolar silencing complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD (+/NADP (+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2 by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Synonyms
NML, KIAA0409
Gene ID
23378
Swiss Prot
O43159
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human RRP8
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
211kDa
Observed Molecular Weight
200kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
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