NGEF Polyclonal Antibody
This is a NGEF Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Acts as a guanine nucleotide exchange factor (GEF which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity.
Synonyms
NGEF, ARHGEF27, EPHEXIN, ephexin-1
Gene ID
25791
Swiss Prot
Q8N5V2
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human NGEF
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
21kDa/27kDa
Observed Molecular Weight
26KDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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