CRTC1 Polyclonal Antibody
This is a CRTC1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Synonyms
CRTC1, MECT1, TORC-1, TORC1, WAMTP1
Gene ID
23373
Swiss Prot
Q6UUV9
Reactivity
Mouse, Rat
Immunogen
Recombinant fusion protein of human CRTC1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:200-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
18kDa/81kDa
Observed Molecular Weight
80-85kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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