Exatecan Intermediate 7

Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs) .

Product Specifications

CAS Number

[182182-32-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/exatecan-intermediate-7.html

Concentration

10mM

Purity

99.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NC(C=C(F)C(C)=C1CC/C2=N\O)=C1C2=O)=O

Molecular Formula

C13H13FN2O3

Molecular Weight

264.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Kamihara, et al. Aminotetralone derivatives and process for producing the same. World Intellectual Property Organization, WO9626181 A1 1996-08-29.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.