HLA-DOB Polyclonal Antibody
This is a HLA-DOB Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Synonyms
HLA-DOB, DOB, HLA_DOB, major histocompatibility complex, class II, DO beta
Gene ID
3112
Swiss Prot
P13765
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human HLA-DOB
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
28kDa/49kDa
Observed Molecular Weight
49kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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