Recombinant Axin 2 Monoclonal Antibody
This is a Recombinant Axin 2 Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Synonyms
AXIN2, AXIL, ODCRCS, axin-2
Gene ID
8313
Swiss Prot
Q9Y2T1
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human Axin 2
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Recombinant Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
143kDa
Observed Molecular Weight
160kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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