HTRA1 Polyclonal Antibody
This is a HTRA1 Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Synonyms
Serine protease HTRA1, High-temperature requirement A serine peptidase 1, L56, Serine protease 11, PRSS11
Swiss Prot
Q92743
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human HTRA1 protein expressed by E.coli
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000, IHC 1:400-1:800
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
77 kDa
Observed Molecular Weight
77 kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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