Recombinant Glucocorticoid Receptor Monoclonal Antibody
This is a Recombinant Glucocorticoid Receptor Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Receptor for glucocorticoids (GC) . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832) . Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546) .
Synonyms
GR, GCR, GRL, GCCR, GCRST
Gene ID
2908
Swiss Prot
P06537
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of mouse Glucocorticoid Receptor
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Recombinant Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000, IF 1:50-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
56kDa
Observed Molecular Weight
51kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
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