NF2 / Merlin Polyclonal Antibody
This is a NF2 / Merlin Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Synonyms
ACN, BANF, Merlin, Neurofibromin 2, neurofibromin 2 (merlin), NF2, SCH, Schwannomerlin, Schwannomin
Gene ID
4771
Swiss Prot
P35240
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human NF2 protein expressed by E.coli.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
2.2mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,50% glycerol, pH 7.4
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
15kDa
Observed Molecular Weight
13kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
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