(KO Validated) HIF1AN Polyclonal Antibody
This is a (KO Validated) HIF1AN Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Synonyms
HIF1AN, FIH1
Gene ID
55662
Swiss Prot
Q9NWT6
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human HIF1AN
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000, IF 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
14kDa
Observed Molecular Weight
14kDa/16kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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