Carglumic Acid
Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.
Product Specifications
CAS Number
1188-38-1
Product Name Alternative
N-Carbamyl-L-glutamic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Carbamoyl Phosphate Synthetase (CPS)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Carglumic_Acid.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(N)=O
Molecular Formula
C6H10N2O5
Molecular Weight
190.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen CT, et al. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015 Nov 15;5 (12) :3560-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CPS I
Available Sizes
Frequently Asked Questions
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