Carglumic Acid

Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

Product Specifications

CAS Number

[1188-38-1]

Product Name Alternative

N-Carbamyl-L-glutamic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Carbamoyl Phosphate Synthetase (CPS)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Carglumic_Acid.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(N)=O

Molecular Formula

C6H10N2O5

Molecular Weight

190.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen CT, et al. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015 Nov 15;5 (12) :3560-9.