L-Moses
L-Moses (L-45), a chemical probe, is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM[1].
Product Specifications
CAS Number
2079885-05-3
Product Name Alternative
L-45
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L-45.html
Purity
99.97
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
C[C@@H]([C@H](C1=CC=CC=C1)N(C)C)NC(C2=C3C=CC=C2)=NN4C3=NN=C4C
Molecular Formula
C21H24N6
Molecular Weight
360.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Moustakim M, et al. Discovery of a PCAF Bromodomain Chemical Probe. Angew Chem Int Ed Engl. 2017 Jan 16;56 (3) :827-831.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Brd
Available Sizes
Frequently Asked Questions
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