MS437
MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions[1].
Product Specifications
CAS Number
[541535-31-3]
Product Name Alternative
HMR-1275; Alvocidib; L86-8275
UNSPSC
12352005
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ms437.html
Purity
98.0
Smiles
O=C(C1=C2C(C=CC=C2)=NC(C3=CC=CC=C3)=C1)N(C(C)C)C(C)C
Molecular Formula
C22H24N2O
Molecular Weight
332.44
References & Citations
[1]Latif R, et al. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25 (1) :51-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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