Ceralasertib

Ceralasertib (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM.

Product Specifications

CAS Number

[1352226-88-0]

Product Name Alternative

AZD6738

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZD6738.html

Purity

99.76

Solubility

DMSO : 70 mg/mL (ultrasonic)

Smiles

O=[S@@](C1(CC1)C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(N5CCOC[C@H]5C)=C2)(C)=N

Molecular Formula

C20H24N6O2S

Molecular Weight

412.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Vendetti FP, et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of CDDP to resolve ATM-deficient non-small cell lung cancer in vivo.|[2]Kim HJ, et al. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. Int J Cancer. 2017 Jan 1;140 (1) :109-119.