D-Saccharic acid 1,4-lactone (hydrate)
Product Specifications
UNSPSC Description
D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-saccharic-acid-1-4-lactone-hydrate.html
Smiles
OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O.O
Molecular Weight
210.14
References & Citations
[1]Taha M, et al. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs. Bioorg Chem. 2016;68:56-63. |[2]Bhattacharya S, et al. Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. J Biochem Mol Toxicol. 2011;25(6):341-354. |[3]Bhattacharya S, et al. D-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic β-cells from apoptosis via mitochondrial dependent pathway. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):272-83.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134453A/D-Saccharic-acid-1-4-lactone-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134453A/D-Saccharic-acid-1-4-lactone-hydrate-SDS-MedChemExpress.pdf
CAS Number
61278-30-6
Available Sizes
Curated Selection
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