D-Saccharic acid 1,4-lactone (hydrate)

D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC50=48.4 μM) . D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2].

Product Specifications

CAS Number

[61278-30-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; β-glucuronidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/d-saccharic-acid-1-4-lactone-hydrate.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O.O

Molecular Formula

C6H10O8

Molecular Weight

210.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Taha M, et al. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs. Bioorg Chem. 2016;68:56-63. |[2]Bhattacharya S, et al. Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. J Biochem Mol Toxicol. 2011;25 (6) :341-354. |[3]Bhattacharya S, et al. D-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic β-cells from apoptosis via mitochondrial dependent pathway. Toxicol Appl Pharmacol. 2011 Dec 1;257 (2) :272-83.