Cinacalcet
Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.
Product Specifications
CAS Number
226256-56-0
Product Name Alternative
AMG 073
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
CaSR; Endogenous Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Cinacalcet.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F
Molecular Formula
C22H22F3N
Molecular Weight
357.41
Precautions
H315, H319, H320
References & Citations
[1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67 (2) :467-76.|[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69 (9) :1586-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Acta Physiol. 2023 Apr;237 (4) :e13926.|bioRxiv. 2025 Sep 21.|Calcif Tissue Int. 2023 Apr;112 (4) :452-462.|Cell Biol Toxicol. 2023 Oct;39 (5) :1-17.|Gen Comp Endocrinol. 2018 Oct 1:267:1-8.|J Agric Food Chem. 2021 Nov 17;69 (45) :13460-13473.|J Biol Chem. 2016 Oct 28;291 (44) :23126-23135.|J Clin Endocrinol Metab. 2024 Oct 16:dgae735.|J Food Sci. 2018 Sep;83 (9) :2394-2401.|J Med Chem. 2015 Apr 9;58 (7) :2958-66. |Oxid Med Cell Longev. 2017:2017:3869561.|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.|Adv Mater. 2024 Jun;36 (24) :e2311760.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|iScience. 2023 Mar 11;26 (4) :106378.|J Funct Foods. 2025 Apr.|Patent. US20230147129A1.
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