β-catenin-IN-3
β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells[1].
Product Specifications
CAS Number
[1005288-15-2]
UNSPSC
12352005
Target
CDK; Wnt; β-catenin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-catenin-in-3.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(N/C=C/C(C=C1Br)=C(C(Br)=C1)O)NC(C2)C3C(C=CC4)C4C2C3
Molecular Formula
C19H20Br2N2OS
Molecular Weight
484.25
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4
Available Sizes
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