Anti-GLO1 | Glyoxalase I (clone 6F10)

Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer’s disease.

Jiang et al. (2018) . Role of the Glyoxalase System in Alzheimer's Disease. J Alzheimers Dis. 2018;66 (3) :887-899. doi: 10.3233/JAD-180413. PMID: 30400091.Hovatta et al. (2005) Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 2005 Dec 1;438 (7068) :662-6. doi: 10.1038/nature04250. Epub 2005 Oct 23. PMID: 16244648.Junaid et al. (2004) Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor. Am J Med Genet A. 2004 Nov 15;131 (1) :11-7. doi: 10.1002/ajmg.a.30349. PMID: 15386471; PMCID: PMC1360505.

Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.