Genistein

Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

Product Specifications

CAS Number

[446-72-0]

Product Name Alternative

NPI 031L

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; EGFR; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Genistein.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1

Molecular Formula

C15H10O5

Molecular Weight

270.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Peterson G, et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7 (10) :1345-51.|[2]Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11 (5) :e0155352.