Anti-2b protein [Cucumber mosaic virus]

2b protein [Cucumber mosaic virus] is one of the first identified suppressors that could inhibit post-transcriptional gene silencing (PTGS), but with little or no effect on miRNA functions. CMV 2b protein also interferes with miRNA pathways, eliciting developmental anomalies.

Pinczés et al. (2024) . Viral coat proteins decrease the gene silencing activity of cognate and heterologous viral suppressors. Sci Rep. 2024 Dec 28;14 (1) :31008. doi: 10.1038/s41598-024-81998-4. Wu et al. (2020) . WUSCHEL triggers innate antiviral immunity in plant stem cells. Science. 2020 Oct 9;370 (6513) :227-231. doi: 10.1126/science.abb7360. PMID: 33033220.Nemes et al. (2019) . Symptom recovery is affected by Cucumber mosaic virus coat protein phosphorylation. Virology Volume 536, October 2019, Pages 68-77.Zhang et al (2006) . Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes & development 20: 3255-3268.

Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.