Anti-ASyM | Mouse anti-human alpha synuclein N-terminal (clone number 4,2)
Product Specifications
Background
Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy.
CAS Number
9007-83-4
HS Code
38221900
Host
Mouse
Reactivity
Human
Not reactive in
No confirmed exceptions from predicted reactivity are currently known
Immunogen
Synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15
Clonality
Monoclonal
Applications
Dot blot (Dot), ELISA (ELISA), Immunohistochemistry (IHC)
Field of Research
Parkinson's disease
Dilution
1-2 µg/ml (Dot), 2-4 µg/ml (ELISA capture), 10 µg/ml (IHC)
Purity
Immunogen affinity purified serum in PBS pH 7.4.
Format
Lyophilized
Reconstitution
For reconstitution add 50 µl of sterile water
Molecular Weight
14 kDa
Additionnal Information
This antibody will recognize human SNCA monomers and multimers in Western blot. This antibody binds weakly to fibrills in IHC.Cross reactivity of this antibody to synuclein beta was not determined.This antibody can be used as a capture antibody in ELISA, combined with AS08 358 as a detection antibody.
References & Citations
Tanudjojo et al. (2021) Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons. Nat Commun. 2021 Jun 21;12 (1) :3817. doi: 10.1038/s41467-021-23682-z. PMID: 34155194; PMCID: PMC8217249.
Storage Conditions
For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Prediction Reactivity
Mouse
Isotype
IgG2a
Documents
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740034-500 1x 500 µL
Cytokeratin 8/18 (C-51), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740745-500 1x 500 µL
CD45 / LCA (2B11 + PD7/26), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740050-100 1x 100 µL
IgA Secretory Component (SC05), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741003-500 1x 500 µL
Mucin 5AC (MUC5AC) (58M1), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 