Anti-HSP101 | ClpB heat shock protein, N-terminal (rabbit antibody)

Hsp101/ClpB is a member of HSP100 protein family. These proteins help protein aggregates formed during heat stress to fall apart to allow them to be refolded by other chaperones. HSP101 is a cytosolic heat shock protein required for acclimation to high temperature.

Szaker et al. (2025) . Transcription fidelity and control of alternative splicing contribute to heat stress survival in Arabidopsis. Plant Cell. 2025 Oct 28:koaf256.doi: 10.1093/plcell/koaf256. Li et al. (2025) . Blocking constitutive autophagy rescues the loss of acquired heat resistance in Arabidopsis fes1a. New Phytologist, Volume245, Issue6 March 2025. Pages 2569-2583. Szadeczky-Kardoss et al. (2022) Elongation factor TFIIS is essential for heat stress adaptation in plants. Nucleic Acids Res. 2022 Feb 28;50 (4) :1927-1950. doi: 10.1093/nar/gkac020. PMID: 35100405; PMCID: PMC8886746.Wang et al. (2022) 17- (Allylamino) -17-demethoxygeldanamycin treatment induces the accumulation of heat shock proteins and alleviates senescence in broccoli. Postharvest Biology and Technology, Volume 186, 2022, 111818, ISSN 0925-5214, https://doi.org/10.1016/j.postharvbio.2021.111818.Fedotova et al. (2020) . Influence of high temperatures on heat tolerance and synthesis of heat shock proteins in spring wheat at the initial stages of development // Siberian Journal of Life Sciences and Agriculture. 2020.12, 5. C. 179-191. DOI: 10.12731/2658-6649-2020-12-5-179-191Gorovits et al. (2020) . Pharmaceuticals in treated wastewater induce a stress response in tomato plants. Sci Rep. 2020 Feb 5;10 (1) :1856. doi: 10.1038/s41598-020-58776-z.McLoughlin et al. (2019) HSP101 Interacts with the Proteasome and Promotes the Clearance of Ubiquitylated Protein Aggregates. Plant Physiol. 2019 Aug;180 (4) :1829-1847. doi: 10.1104/pp.19.00263

Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.