Anti-HSP70/HSC70 | Heat shock protein 70/Heat shock cognate protein 70 (serum)
Selected Variant
AS05 083
Size: 100 µL
Product Specifications
Background
Heat shock protein 70 (Hsp70) is the major stress-inducible protein in vertebrates and is highly conserved throughout evolution. It plays a role as a molecular chaperone and is important for allowing cells to cope with acute stress or insult, especially those affecting the protein machinery. Heat shock cognate protein 70 (HSC70) is a highly conserved protein and a member of the family of molecular chaperones. Alternative names: HSP70.1, HSP70-1/HSP70-2, Heat shock 70 kDa protein 8
CAS Number
9007-83-4
HS Code
38221900
Host
Rabbit
Reactivity
Fish, mammals, fungi: Antrodia infirma, A. sinuosa, A. xantha, Catostomus commersonii, Gloeophyllum protractum, Gloeophyllum sepiarium, G. carbonarium, Junghunia luteoalba, Oligoporus sericiomollis, Phlebia cornea
Not reactive in
No confirmed exceptions from predicted reactivity are currently known
Immunogen
KLH-conjugated synthetic peptide conserved across all known sequences of HSP70 P08107 and HSC70 proteins P11142
Clonality
Polyclonal
Applications
Immunoprecipitation (IP), Western blot (WB)
Field of Research
Fish Proteins
Dilution
1 : 1000 (IP), 1 : 1000-1: 5000 (WB)
Purity
Total IgG. Protein G purified in PBS pH 7.4.
Format
Lyophilized
Reconstitution
For reconstitution add 100 µl of sterile water
Molecular Weight
70 kDa
Precautions
This antibody is recognizing both, the inducible and the constitutive Hsp70
Additionnal Information
For detection of plant and algal cytoplasmic hsp70 we recommend following product: AS08 371.
References & Citations
MacLellan et al. (2015) . Chaperone roles for TMAO and HSP70 during hyposmotic stress in the spiny dogfish shark (Squalus acanthias) . J Comp Physiol B. 2015 Jun 7.Bessemer et al. (2014) . Cardiorespiratory toxicity of environmentally relevant zinc oxide nanoparticles in the freshwater fish Catostomus commersonii. Nanotoxicology. 2014 Nov 27:1-10.Gorovits et al. (2013) . Recruitment of the host plant heat shock protein 70 by tomato yellow leaf curl virus coat protein is required for virus infection. PLoS Once, July 23;8 (7) .
Storage Conditions
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Prediction Reactivity
Bovine, Drosophila melanogaster, Hen, Mouse, Rat
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