Anti-FVIIa | Coagulation factor VIIa (50 µg)
Product Specifications
Background
Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. FVIIa requires tissue factor (TF), a membrane bound protein, as an essential cofactor for maximal activity towards its biological substrates Factor X, Factor IX and Factor VII (FVII) .
CAS Number
9007-83-4
HS Code
38221900
Gene ID
835165
UniProt
Q9FI56 , Q9SXJ7
Host
Rabbit
Reactivity
Human
Not reactive in
No confirmed exceptions from predicted reactivity are currently known
Immunogen
Recombinant human Factor VIIa (NovoSeven ®, Novo Nordisk A/S Denmark)
Clonality
Polyclonal
Applications
Prothrombin assay with human plasma (PT), thrombin generation assay, inhibition assay with Factor VIIa with TF and a chromogenic substrate, inDirect ELISA (I-ELISA)
Field of Research
Immunology
Dilution
1 : 15 000 (I-ELISA), 14 µg/ml (IL)
Purity
Immunogen affinity purified IgG in PBS pH 7.4.
Format
Lyophilized
Reconstitution
For reconstitution add 50 µl of sterile water
Molecular Weight
52 kDa (this is MW of Factor VIIa)
Precautions
This antibody is purified using Protein G, to obtain a total IgG fraction
Additionnal Information
No significant difference in binding to Factor VII and Factor VIIa.Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
References & Citations
Lopez-Vilchez et al. (2009) . Traffic of rFVIIa through Endothelial Cells and Redistribution into Subendothelium: Implications for a Prolonged Hemostatic Effect. Journal of Coagulation Disorders, October 1: (1) . (immunolocalization)
Storage Conditions
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them, to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Prediction Reactivity
Primates
Documents
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