Phospho-ATM (Ser1981) Polyclonal Antibody
This is a Phospho-ATM (Ser1981) Phospho-Specific Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Synonyms
A-T mutated, A-T mutated homolog, AT mutated, AT1, ATA, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, ATM, DK
Swiss Prot
Q13315
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Phospho-Specific Antibody
Applications
WB, IHC-p, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Observed Molecular Weight
350 kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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