AKT1 Monoclonal Antibody
This is a AKT1 Monoclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Synonyms
AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha
Swiss Prot
P31749
Reactivity
Human
Immunogen
Synthetic Peptide of AKT1
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
WB, IHC-p
Purification Method
Protein A purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:1000-2000, IHC 1:100-200
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Observed Molecular Weight
60 kDa
Host or Source
Mouse
Isotype
IgG
Available Sizes
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